How High Cholesterol Can Be Healthy, and Low Cholesterol Could be Harmful, with Dave Feldman.
If you are interested in lipids, you’ve probably heard of Dave Feldman and his work. If not, you’ve got some homework to do, and I think you’ll be amazed at what you find. Dave’s work can be found at cholesterolcode.com where he details his multiple, meticulous self-experimental projects. Prior to cholesterol adventures Dave was a senior software scientist and an engineer. He brings this “out of the box” thinking to the world of medicine and we are all better off for it.
He began a low-carb, high-fat diet in April 2015 and has since learned everything he could about it with special emphasis on cholesterol. He saw his own lipid numbers spike substantially after going on the diet and spotted a pattern in the lipid system that’s very similar to distributed objects in networks.
0:08:46 Podcast Begins
0:14:21 The Bradford Hill Criteria
0:15:29 Context matters in lipids
0:19:44 Carnivore MD's Lipid Panel
0:30:15 Why LDL can't be the root cause of CVD
0:35:57 Testing the Lipid Hypothesis
0:41:20 Why you can't look at LDL in a vacuum
0:47:38 High-density lipoprotein as a protective factor against coronary heart disease The Framingham study - The Framingham Study https://www.amjmed.com/article/0002-9343(77)90874-9/pdf
0:49:19 Metabolic health is what really matters
0:52:01 Premature Atherosclerosis Associated With Monogenic Insulin Resistance https://www.ahajournals.org/doi/10.1161/01.cir.103.18.2225?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed&
0:54:19 LDL quality is what actually matters
1:00:39 What's the root cause of oxidized LDL?
1:06:20 Why most LDL lab tests are bonk!
1:07:41 Dave's latest experiment results
1:16:12 Summary of Dave's Energy Model
1:21:21 The body holds onto and reuses cholesterol.
1:24:28 The vital importance of ample cholesterol
1:25:40 Fasting Increases Serum Total Cholesterol, LDL Cholesterol and Apolipoprotein B in Healthy, Nonobese Humans https://academic.oup.com/jn/article/129/11/2005/4721856
1:26:19 Brown Bears (Ursus arctos) Seem Resistant to Atherosclerosis Despite Highly Elevated Plasma Lipids during Hibernation and Active State https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439871/
1:28:40 Strong increase in hydroxy fatty acids derived from linoleic acid in human low-density lipoproteins of atherosclerotic patients https://pubmed.ncbi.nlm.nih.gov/9488997/
1:30:45 Why PUFAs lower LDL and why this is a bad thing
1:32:56 Changes in Dietary Fat Intake Alter Plasma Levels of Oxidized Low-Density Lipoprotein and Lipoprotein(a) https://www.ahajournals.org/doi/10.1161/01.ATV.0000118012.64932.f4?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
1:32:56 Variables beyond LDL-- Lp(a)
1:37:50 Quantification of apo[a] and apoB in human atherosclerotic lesions https://www.jlr.org/content/32/2/317.long
1:42:51 Metabolic health greatly influences lipids
1:45:18 Citizen Science Foundation https://citizensciencefoundation.org/
1:47:58 Dave, the Radical human test tube!